Homelander should be a better fighter up close, since he could throw hands with Soldier Boy who has actual military training and Billy Butcher at the same time.
Tighten is some random dude that has zero hand to hand combat training. The "training" Megamind gave him was for him getting used to his powers. Megamind himself has no real good combat feats and both are shown to be, well very goofy in their fighting styles, which are very ineffective.
However, it's not like Homelander skill stomps him. He's no better than real life trained soldiers, who can still be hit by normal people. But in this case, Tighten is stronger and crushes him with his LS. He'll have more confidence when he notices that Homelander is noticeably weaker than him and can overpower him with LS.
Homelander loves to grapple with people, so it won't take Tighten long to realize he can effortlessly overpower Homelander and just hold him down. The fight is basically over at that point and Homelander isn't good enough to take down Tighten before he realizes this, yes even despite how dumb he is.
Voting for Tighten here.