Ok so;
Ayanokouji has extensive experience dealing with weapons, so this would be nothing new to him. He has fought the world's top-ranked individuals in their respective fields, all of whom were geniuses themselves, and completely curb-stomped them to the point where they looked like children compared to Ayanokouji's skill level in both hand-to-hand combat and weapon mastery. He accomplished this in just five years and continued evolving at the same rate for the remainder of his time in the White Room.
Not only that, but Ayanokouji has shown the ability to remain completely untouched against opponents comparable to him in skill, even when those opponents had full prior knowledge of his abilities, including his decision-making, fighting style, physical stats, and more. While severely weakened—tired, hungry, thirsty, and fighting under the blazing sun—he still remained untouched. Tsukishiro, in particular, could effectively "mind-read" his opponents through cold reading, allowing him to infer what they were thinking. Despite this, Ayanokouji continuously adapted and countered Tsukishiro's predictions (while Tsukishiro was also countering him) and still managed to avoid being hit.
A counterpoint to what Zefra said is that Ayanokouji currently has two weapons: a baton and a knife. He could block a sword strike with the baton while simultaneously attacking with the knife. He could also incorporate feints into his offense, which I'm not sure Iris has any feats for, but they could be effective. Additionally, Ayanokouji could simply discard the knife and immediately go for a disarm, as self-defense techniques commonly include methods for disarming armed opponents.
As for Iris's analysis of him, I believe Ayanokouji could counter that as well. He has feats that support this. For example, after only a few exchanges with Nanase, he realized she possessed kinetic vision. He also noticed
details as subtle as a student's blood vessels constricting and their pupils dilating from across the room, allowing him to determine exactly what their brain was registering. The reason I bring this up is because Ayanokouji's AD would allow him to counter Iris's analysis, just as he did against Tsukishiro and Shiba. As mentioned earlier, both of them had full prior knowledge of his capabilities and based their predictions on that information, with Tsukishiro further enhancing his predictions through cold reading. In response, Ayanokouji began creating entirely new timings, habits, and an unorthodox fighting style, along with other adaptations, to invalidate their predictions and render them ineffective.
