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Superman may be a Kryptonian so we don't know his exact physiology, but he is still a mammal. Severe dehydration in mammals (especially rapid dehydration in this case) leads to organ damage and organ failure.
I propose his regen go from mid-low to high-low, which doesn't conflict with Doomsday stabbing him through the heart.
High-Low: The ability to regenerate severed fingers, toes, or ears, minor organ damage, and even potentially reattach lost limbs.
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