Kars options are D4C (move to a different world and have duplicates fight in his stead, move Eldrad to a different world then just leave (he can layer worlds) fir BFR, or use D4C clones to paradox out of existence),
The world time stop (he even arms his duplicates with this usually, at the end ioff the novel he had duplicates all armed with the world help him, he can also use time stop to avoid precognition, dio did this against Diavolo even saying his precog is useless before it) he can also use other stands within timestop if dio is anything to go by.
Killer Queen BTD, transmutation+atomization to everyone around him+time rewind (the transmutation atomization happens regardless each time unless he undoes it). Or simply touching within timestop and turning him into a bomb.
Whitesnake can remove souls and minds, and also destroy them on contact (Kars can also ansorb souls and read mind's, kars himself can also simply reach in and remove souls, Kars can also survive as just a soul and survive without a soul, how does it work? Hell if i know).
Or MIH to accelerate his speed (can focus the effect to just himself) or use it to cause the death of the universe (he'd be smart to equip a clone with Mih and piss off to an alternate world and have clones do it in his stead).
Basically time stop+whatever is needed, he has enough time to test that out if need be.
Also Kars resists others time stop and can counter with time stop. Can survive without a soul (or mind, but not sure how long the latter last for, at leaat a minute or two, ignoring his already good resistance), also resists willpower manipulation (specifically that has no effect on him from anything below low 2-C/High 3-A plus high 3-A/low 2-C causility manipulation).
Basically, yeah the one can one shot physically (ignoring Kars can survive without a body), but Kars can just time stop and go wild and this dude has no resustances listed on his profile.