I’m absolutely voting for Psykos here.
To begin with, Psykos holds a significant advantage in raw power. Her AP is alarmingly close to the threshold of one-shotting Deku — specifically, she's operating at a 1.1x gap from reaching that level. That alone places Deku at extreme risk, as any meaningful exchange of blows tilts the tides heavily in her favor. Additionally, Psykos' psychic energy acts as a form of
very potent durability negation, causing severe internal damage to opponents on her level and stronger. Just a few moments of exposure is enough to bring them to the brink of death, and she's
capable of keeping him in an enclosed space filled with it for however long she pleases.
Now, consider her
AoE and
sheer scale. Psykos’ omnidirectional danmaku,
which directly parallels the complexity of the human brain’s neural network at minimum, can grow to
planetary sizes over a relatively short period of time. This makes Deku’s analytical predictions mostly useless on their own meaning that he'd have to rely on his speed amps. This won't work on her either for several reasons:
First, Psykos is
constantly protected by a barrier so durable that
even Tatsumaki herself took note of its toughness. Deku’s strongest attacks wouldn’t even make it past this defense. Second, even if he somehow manages to bypass the barrier, unless he resorts to exclusively long-range attacks like shockwaves or something similar he’s as good as finished.
Any physical contact would result in him being absorbed on the spot. And to make matters worse, Psykos’s regeneration is simply too overwhelming for Deku to do any real or lasting harm — even attacks that damage the soul aren’t enough, as she’s
tanked soul damage from Orochi without issue.
But let’s play devil’s advocate. Even if Deku somehow bypasses her durability, her regeneration, and her barriers, her AP, and her danmaku (among others), he'd still be faced with an near-impossible task: he’d need to
figure out how to separate Psykos from her roots before she completes her planetary fusion. If she fuses, the fight is over — Deku’s win condition vanishes entirely. And
even then, as if that weren’t enough: Psykos also has Type 2 immortality, which Deku has absolutely no reliable counter to.
All in all, Psykos just has way too many win conditions and layers of overwhelming advantage for Deku to handle. It’s a clear victory for her.