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It wouldn't do much since in this key Andy's reliant on his brain and undead to regenerate. Basically attacking the soul isn't what will negate the regeneration.How would Andy's regen interact with the soul-slashing properties of Dragon Slayer?
Yeah his regen relies on Undead/his brain. His soul being damage doesn't really matter and at this point in the story he doesn't believe souls are what give one life, he believes that when the brain stops thats when someone is dead. So Guts would need to destroy his brain repeatedly and after that find some way to trap Andy.If he isn't able to heal wounds to his Astral body I don't see how that would negate Dragon Slayer, unless Andy's regeneration is reliant on some kind of hax ability that goes beyond that.