Versatility is the only thing in favor of All for One. But does he have an answer for Luffy's active pre-cog? Also, a handful of his abilities will struggle to even hurt Luffy, who is resistant to all manner of (blunt) physical trauma.
Luffy's intellect in combat is nothing to scoff at. He's a completely different person outside of it. All For One may be more experienced, but he has no information on Devil Fruits or Haki.
AP gap being small is hardly a problem considering the fact that Luffy has stronger AP with specific attacks like King Kong Gun (which he can currently use without more than mild strain from what is seen), and he outright ignores durability with his newfound ability via Goken: an application of Busoshoku that emits the user's haki outwards. Its most basic usage is barrier creation, but Luffy has developed it to the point where he can inject his Haki into a target object/body and basically disintegrate it from the inside.
Also, Luffy's Gear 4th appears to no longer have any weakness regarding a time-limit or temporary Haki deactivation. Last time we saw him use it, he entered the state on a whim for a few seconds, then when he reverted, he behaved normally.
Also, speed equalization only applies to their base speed (Well in this case, Luffy starts in Gear 2nd). Luffy can use Soru in Gear 2nd to move at increased speeds, and he can also use Gear 4th which is even faster than Gear 2nd.
Luffy's advantages are very clear. His pre-cog and speed advantage will make it so he is always a couple steps ahead of All for One, his blunt force resistance will render some of AFO's abilities useless--not to mention his Haki + Elasticity harmonization will also resist against cutting attacks because he is armored and rubbery at once, Luffy's AP is inherently better in Gear 4th, and more-so when factoring in his King Kong Gun and ability to just destroy opponents from the inside.
AFO may have warp, but this is quite useless to someone who has superior physical speed and pre-cog, so Luffy would just clock him the moment he's appeared in a location.
Luffy takes this.